What is the side effect of Entresto

Introducing Entresto

What is Entresto?

Entresto is a combination medicine made from sacubitril and valsartan. The drug from Novartis Pharma GmbH is used to treat heart failure.

How is Entresto used?

Entresto is an oral medicine in tablet form. The tablets are taken twice a day, with the usual starting dose being one 49 mg / 51 mg tablet twice a day. After two to four weeks of intake, the dose is doubled to 97 mg / 103 mg. If necessary, a lower dosage of 24 mg / 26 mg can also be used.

How does Entresto work?

The two active ingredients work in different ways, sacubitril inhibits the breakdown of the natriuretic peptides produced in the body. This increases the excretion of water and sodium and relieves the heart. The natriuretic peptides also lower blood pressure and prevent the development of fibrosis. Valsartan is an angiotensin II receptor antagonist. By doing this, valsartan stops the hormone's harmful effects on the heart and also lowers blood pressure by widening the blood vessels.

Study results Entresto

The main study compared Entresto with enalapril. Since Entresto was more effective than enalapril, the study could be stopped early.

Side effects of Entresto

High potassium levels, low blood pressure and kidney problems are very common. Angioedema occasionally occurs. All side effects are included in the product information and instructions for use.


Entresto must not be taken with ACE inhibitors. In addition, patients who have had angioedema or who have severe liver problems should not take this medicine. Pregnant women are also not allowed to use Entresto.