I have a hormone deficiency

Causes of Hormone Deficiency

The endocrine gland is missing

Missing endocrine glands can be a cause of hormone deficiency. A hormonal gland can either be absent from birth or removed or destroyed in the course of life, for example if a gland is affected by a tumor and has to be removed by surgery.

Glandular tissue is destroyed or displaced

Certain diseases can cause hormonal glands to be destroyed. Autoimmune diseases such as B. Graves disease or Addison's disease, the cause. The body's own immune system attacks the glandular tissue and damages it. In type 1 diabetes, the immune system destroys the insulin-producing cells in the pancreas. Other causes of the destruction of hormonal glands are:

  • Circulatory disorders
  • Internal bleeding
  • stroke
  • Infections (e.g. inflammation of the thyroid gland, tuberculosis)
  • Tumors

The production of hormones is disturbed

The body makes hormones with the help of certain proteins called enzymes. Without these enzymes it cannot make certain hormones.

Some enzymes are absent from birth, others are not sufficiently formed as a result of illnesses. For example, if the kidneys are weak, the kidneys are damaged so that they no longer produce enough calcitriol. Since calcitriol regulates the calcium balance, not enough calcium is built into the bones (Osteomalacia).

Even if the building blocks from which the body composes the molecules are missing, some hormones cannot be made. An important building block for hormone production is z. B. iodine. If a person does not get enough iodine with their food, their thyroid will not be able to produce enough hormones. The result is an underactive thyroid.

The hormones are not working properly on their target cells

Hormones bind to certain molecules in the cell membrane called receptors. If these receptors are insufficient or defective, a hormone cannot work properly. This can e.g. B. be the case with type 2 diabetes. Another example is testicular feminization (complete androgen resistance). The affected person's body does not form any receptors for the male sex hormone testosterone. The genetic sex of these people is male, but no male sex organs are formed because the testosterone cannot work. So the newborns look like girls.